CELLULOSE ACETATE PHTHALATE BASE ENTRIC COATING POLYMER
» UNICOAT CEC IS CAP(CELLULOSE ACETATE PTHALATE) BASE ENTRIC COATING POLYMER.
» Cellulose acetate phthalate, also known as cellacefate is the oldest and most widely used synthetic enteric coating polymer CAP is insoluble in water, alcohols, hydrocarbons, and chlorinated hydrocarbons but soluble in ketones, ethers, alcohols, esters, and in certain solvent mixtures. It exhibits
rapid dissolution at a pH > 6 and is relatively permeable to moisture and gastric juices. Due to its high moisture permeability, CAP is susceptible to hydrolytic decomposition.
» Phthalic and acetic acid molecules may hydrolyse during storage and significantly compromise the degree of enteric protection that the film coating provides. The addition of a plasticizing agent has been shown to improve the water resistance of CAP films.
Reconstitution Level 10.0% Avg. Weight Gain 7 – 8
| Conventional Coater | Auto Coater | Conventional Coater | Auto Coater | Auto Coater | |
| COATING EQUIPMENT | 12″ PAN | 24″ PAN | 36″ PAN | 48″ PAN | 60″ PAN |
| PAN Speed (rpm) | 18- 20 | 10-14 | 8-12 | 3-5 | 1.5-3 |
| Tablet Charge ( Kg ) | 0.5 – 1 | 10-15 | 40-50 | 100-130 | 250-300 |
| Tablet Bed Tempreature(°C) | 38-42 | 38-42 | 38-42 | 38-42 | 38-42 |
| Spray Rate (g/min) | 20-10 | 50-70 | 100-140 | 300-350 | 550-700 |
| Inlet Air Tempreature(°C) | 60-65 | 60-65 | 60-65 | 60-65 | 60-65 |
| Weight gain (%) on Tablet | 7-8 | 7-8 | 7-8 | 7-8 | 7-8 |
